Disease and Economic Burden Associated with Recurrent Pericarditis in a Privately Insured United States Population

Figures

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  Fig. 1. Study design scheme for A patients in the multiple recurrences cohort and B patients in the no recurrence cohort

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  Fig. 2. Patient selection and disposition. ED emergency department, HMO health maintenance organization, RP recurrent pericarditis. 1. Relevant drug and medical claims may not be captured under HMO or Medicare plans coverage. 2. With a first pericarditis claim specifying non-idiopathic pericarditis or a condition or procedure related to non-idiopathic pericarditis (non-mutually exclusive) on or in the 90 days prior to the index date. 3. Cardiac syndromes or procedures were evaluated in the 30 days prior to the index date. 4. All pericarditis claims occurring in sequence without a gap of 4 weeks were considered an episode of care. A recurrence was a subsequent episode of care occurring > 4 weeks after the end of the previous episode of care

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  Fig. 3. Kaplan-Meier rates of persistent disease stratified by number of recurrences

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  Fig. 4. All-cause direct healthcare and work loss costs in the multiple recurrences versus no recurrence cohort during follow-up. CI confidence interval, ED emergency department, PPPM per patient per month, RP recurrent pericarditis, USD US dollars. 1. Evaluated over a mean disease duration post-second recurrence of 12.7 months in the multiple recurrences cohort and over 27.9 months of observation in the no recurrence cohort. 2. Sample size (N) for indirect costs corresponded to the number of employees with work loss coverage. 3. Evaluated over a mean disease duration post-second recurrence of 10.3 months in the multiple recurrences cohort and over 21.1 months of observation in the no recurrence cohort. 4. Includes transportation, dentist, laboratory, home healthcare, and everything not previously identified

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  Fig. 5. Healthcare and work loss costs per episode of care among patients in the multiple recurrences cohort (N = 375). RP recurrent pericarditis, SD standard deviation, USD US dollars. 1. Total sample size for direct healthcare costs. 2. Total sample size for work loss costs (i.e., number of patients with work loss coverage)