Why the study?
Bifidobacterium animalis subsp. lactis GCL2505 improves intestinal microbiota and reduces visceral fat, but its effects alongside inulin on vascular endothelial function needed evaluation.
Does daily ingestion of Bifidobacterium animalis subsp. lactis GCL2505 and inulin improve flow-mediated dilation in healthy subjects?
Does daily ingestion of Bifidobacterium animalis subsp. lactis GCL2505 and inulin improve flow-mediated dilation in healthy subjects?
Daily ingestion of a test drink containing Bifidobacterium animalis subsp. lactis GCL2505 and inulin for 12 weeks significantly improved flow-mediated dilation in healthy subjects.
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May enhance endothelial function in healthy adults; extends synbiotic data but hypothesis-generating pending primary-endpoint confirmation.
Bifidobacterium animalis subsp. lactis GCL2505 (GCL2505) improves the intestinal microbiota and reduces human visceral fat. This randomized, double-blind, placebo-controlled, parallel-group study was conducted to examine the effects of inulin, a prebiotic dietary fiber, and GCL2505 on vascular endothelial function in healthy subjects (n = 60). The test drink contained 2.0 g/100 g inulin and 1.0 × 1010 colony-forming units/100 g GCL2505 and was consumed daily for 12 weeks. Flow-mediated dilation was set as the primary endpoint. Subgroup analysis of vascular endothelial function demonstrated a significant increase in the change of flow-mediated dilation (%) from weeks 0 to 12 in the GCL2505 and inulin group (n = 24) compared with the placebo group (n = 23), while an improving trend in low-density lipoprotein cholesterol and plasminogen activator inhibitor-1 were confirmed. Our results indicated that the test drink had a positive effect on vascular endothelial function and related blood parameters.
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Azuma et al. (2023) studied this question.
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