Key result
Preoperative management of antithrombotic therapy requires an individualized assessment balancing thromboembolic and bleeding risks to determine therapy interruption and bridging strategies.
Why the study?
Preoperative management of antithrombotic therapy is challenging because discontinuation risks thromboembolism while surgery risks bleeding, requiring an individualized balance between risks and decisions on timing and bridging.
Individualized assessment of bleeding and thromboembolic risks is required for the preoperative management of antithrombotic therapy in patients undergoing elective non-cardiac surgery.
Supports individualized antithrombotic decisions preoperatively; leaves open optimal bridging protocols for prospective validation.
Preoperative management of antithrombotic therapy (antiplatelet and anticoagulant therapy) is challenging since discontinuation of therapy carries a risk of the thromboembolic event and surgery carries a risk of bleeding.An optimal balance between thromboembolic and bleeding risk must be reached and the decision whether to stop antithrombotic therapy or not be made.Each patient requires an individual assessment.That means estimating bleeding and thromboembolic risk for each patient.Bleeding risk is based on patient-related risk factors and risk associated with the surgical procedure.Thromboembolic risk is more complex to calculate.If the decision is to stop antithrombotic therapy, the next question is how long before the surgery it should be stopped and whether the bridging therapy is required.
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Živadinović et al. (2022) conducted a review in Patients on chronic antithrombotic therapy requiring elective non-cardiac surgery. Preoperative management of antithrombotic therapy was evaluated. Preoperative management of antithrombotic therapy requires an individualized assessment balancing thromboembolic and bleeding risks to determine therapy interruption and bridging strategies.
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