What does this research mean for the field?

Domain movements in proteins are produced by combinations of basic low-energy conformational changes, specifically hinge and shear motions, which are primarily determined by the structure of the interfaces between the domains. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 7, 1994Biochemistry

Structural Mechanisms for Domain Movements in Proteins

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Population

Proteins for which there is crystallographic evidence for domain movements

Design

Review

Authors

Mark GersteinYale University ALArthur M. LeskPennsylvania State University CCC. ChothiaMRC Laboratory of Molecular Biology

Discussion

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Implication

Informs protein dynamics modeling in research; leaves open validation for cardiovascular applications.

Structured PICO

Population

Proteins for which there is crystallographic evidence for domain movements

Provides a structural framework for understanding domain movements in proteins based on hinge and shear motions.

Cite This Study

Gerstein et al. (1994) studied this question.

synapsesocial.com/papers/6a1abc7c9fa30811a0b90cd2 https://doi.org/10.1021/bi00188a001

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Bookmark

Structural Mechanisms for Domain Movements in Proteins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Structural Mechanisms for Domain Movements in Proteins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider