What question did this study set out to answer?

To evaluate the relationship between the severity of age-related white matter changes and objective measures of gait and balance in nondisabled older individuals.

March 17, 2008ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)

Association of gait and balance disorders with age-related white matter changes

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Authors

HBHansjörg BäeznerUniversity of Helsinki CBChristian BlahakUniversity of Mannheim APAnna PoggesiAzienda Ospedaliero-Universitaria Careggi

Discussion

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Implication

Multicenter prospective study demonstrates worse gait and balance with severe white matter changes in older adults, suggesting physical activity may mitigate mobility decline.

Key Points

To evaluate the relationship between the severity of age-related white matter changes and objective measures of gait and balance in nondisabled older individuals.
Prospective multicenter cohort of 639 nondisabled individuals aged 65 to 84 years enrolled across 11 European centers and followed for 3 years.
Brain MRI scans were centrally evaluated to classify white matter changes into mild, moderate, or severe categories.
Gait and balance were objectively measured using the Short Physical Performance Battery (SPPB, range 0–12), a timed 8-m walk, and a timed single leg stance test.
SPPB scores worsened significantly with greater white matter change severity (mild: 10.2 ± 2.1, moderate: 9.9 ± 2.0, severe: 8.9 ± 2.6; p < 0.001).
Walking speed (mild: 1.24 ± 0.28, moderate: 1.18 ± 0.32, severe: 1.09 ± 0.31 m/s; p < 0.001) and single leg stance time (mild: 18.9 ± 10.8, moderate: 16.4 ± 10.8, severe: 13.6 ± 11.2 s; p < 0.001) both declined as severity increased.
In physically inactive participants, the odds of a pathologic SPPB score increased with disease severity (moderate vs mild: OR 1.60, 95% CI 1.02 to 2.52; severe vs mild: OR 1.75, 95% CI 1.09 to 2.80).

Cite This Study

Bäezner et al. (2008) studied this question.

synapsesocial.com/papers/6a1ac0167ff99bba06461e82 https://doi.org/10.1212/01.wnl.0000305959.46197.e6

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Implication

Multicenter prospective study demonstrates worse gait and balance with severe white matter changes in older adults, suggesting physical activity may mitigate mobility decline.

Association of gait and balance disorders with age-related white matter changes

Discussion

Member takes

Implication

Key Points

Cite This Study

Association of gait and balance disorders with age-related white matter changes

Discussion

Member takes

Implication

Key Points

Cite This Study

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