Key result
Screening first-degree relatives for unruptured intracranial aneurysms is not advised due to low rupture risk.
Why the study?
Screening for unruptured intracranial aneurysms is effective for first-degree relatives of patients with aneurysmal subarachnoid hemorrhage, but whether it is also effective for relatives of patients with unruptured intracranial aneurysms is unknown.
Does screening for UIA with MRA identify high-risk aneurysms and affect quality of life in first-degree relatives of patients with UIA?
Population
First-degree relatives aged 20-70 years of patients with UIA without a family history of aSAH
Comparison
MRA screening vs reference group from the general population for QoL
Design
Prospective multicenter cohort study
Follow-up
1 year
Authors
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Does not support routine screening of first-degree relatives; leaves open whether refined models improve risk stratification.
Cohort
Yes
Does screening for UIA with MRA identify high-risk aneurysms and affect quality of life in first-degree relatives of patients with UIA?
Effect estimate: statistic 0.76 (95% CI 0.65-0.88)
Screening first-degree relatives of patients with unruptured intracranial aneurysms is not advised as identified aneurysms have low rupture risk, though screening does not negatively impact quality of life.
Mensing et al. (2023) conducted a cohort in Unruptured intracranial aneurysms. Magnetic resonance angiography screening vs. General population reference group was evaluated on UIA prevalence, UIA risk at screening, and quality of life (statistic 0.76, 95% CI 0.65-0.88). Screening first-degree relatives of patients with unruptured intracranial aneurysms is not advised due to low rupture risk, despite a risk prediction model yielding a statistic of 0.76 (95% CI 0.65-0.88).
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