Why the study?
Does varying left ventricular end diastolic and peak systolic pressures affect action potential duration in an isolated ejecting guinea pig heart model?
Does varying left ventricular end diastolic and peak systolic pressures affect action potential duration in an isolated ejecting guinea pig heart model?
Raised end diastolic pressure significantly shortens action potential duration in an ejecting whole heart model, suggesting a mechanism for arrhythmogenesis in heart failure via contraction-excitation feedback.
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Hypothesis-generating for contraction-excitation feedback in HF arrhythmogenesis; human studies needed before clinical relevance.
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Coulshed et al. (1991) studied this question.
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