Provides a historical overview of the development and expanding indications of growth hormone therapy.
Historical overview of GH therapy informs evolving use; leaves open prospective validation of expanded indications.
Although the importance of the pituitary gland for growth was recognized in late 19(th) century, Growth hormone (GH) therapy was made available for severely GH-deficient children and adolescents only in late 1950s. Use of GH for other conditions was limited because of the limited supply of human pituitary-derived hormone. With unlimited availability of recombinant human GH (rhGH), the scenario of GH treatment has been changed enormously. Currently there is ever increasing list of indications of GH treatment in children, adolescents, and adults.
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VageeshS Ayyar (2011) studied this question.
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