A Novel Intelligent Two-Way Communication System for Remote Heart Failure Medication Uptitration (the CardioCoach Study): Randomized Controlled Feasibility Trial

Randomized Controlled Trial"?(if not, explain the reason under "other") yes Anders: 1a-i) Identify the mode of delivery in the title Identify the mode of delivery.Preferably use "web-based" and/or "mobile" and/or "electronic game" in the title.Avoid ambiguous terms like "online", "virtual", "interactive".Use "Internet-based" only if Intervention includes non-web-based Internet components (e.g.email), use "computer-based" or "electronic" only if offline products are used.Use "virtual" only in the context of "virtual reality" (3-D worlds).Use "online" only in the context of "online support groups".Complement or substitute product names with broader terms for the class of products (such as "mobile" or "smart phone" instead of "iphone"), especially if the application runs on different platforms.1 2 3 4 5 subitem not at all important essential Does your paper address subitem 1a-i?*Copy and paste relevant sections from manuscript title (include quotes in quotation marks "like this" to indicate direct quotes from your manuscript), or elaborate on this item by providing additional information not in the ms, or briefly explain why the item is not applicable/relevant for your study A two-way communication system was developed, which was both webbased and mobile.Web-based: "All information gathered via the CardioCoach smartphone application (vital signs, questionnaires, medication intake, etc.) is automatically transmitted to a secured online health management server (i.e.Remecare) without patient input."this server could be consulted by both the technical and clinical call center.Mobile: Patients received a smartphone with remote monitoring sensors. 1a-ii) Non-web-based components or important co-interventions in titleMention non-web-based components or important co-interventions in title, if any (e.g., "with telephone support").1 2 3 4 5subitem not at all important essential Does your paper address subitem 1a-ii?Copy and paste relevant sections from manuscript title (include quotes in quotation marks "like this" to indicate direct quotes from your manuscript), or elaborate on this item by providing additional information not in the ms, or briefly explain why the item is not applicable/relevant for your studyHome nurses informed the patient about the use of the smartphone (application) and remote monitoring sensors.In case of deviating parameters, a phone contact was initiated by the heart failure nurse.In case of technical issues or non-compliance, the technical call center contacted the patient.