Key result
Among patients with psychotropic drug-induced torsade de pointes, 73% had more than two risk factors prior to drug initiation, with female gender being the most common (71.4%).
Why the study?
What is the prevalence of risk factors for torsade de pointes in patients who develop it after taking psychotropic drugs?
Systematic Review (n=70)
What is the prevalence of risk factors for torsade de pointes in patients who develop it after taking psychotropic drugs?
Answers are grounded in this paper and cite their sources.
The majority of patients who develop torsade de pointes from psychotropic drugs have multiple identifiable risk factors prior to initiation, highlighting the need for pre-treatment screening.
OBJECTIVE: To investigate all published case reports of torsade de pointes (TdP) induced by psychotropic drugs (PDs) in order to examine the prevalence of risk factors for TdP prior to the drug initiation. METHOD: We found 45 reports on 70 patients with TdP induced by PDs. Each report was analyzed for the presence of risk factors for TdP: female gender, heart disease, hypokalemia, high doses of offending agent, concomitant use of a QT interval prolonging agent, and a history of long-QT syndrome. RESULTS: Female gender was the most common risk factor for TdP (71.4%). The other studied risk factors were also frequently present (34.2-14.2%). Nearly all patients had at least one and 51 (73%) patients had >2 risk factors for TdP prior to PD initiation. CONCLUSION: We wish to raise the level of awareness of risk factors for TdP in the psychiatric community.
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Justo et al. (2005) conducted a systematic review in Torsade de pointes induced by psychotropic drugs (n=70). Psychotropic drugs was evaluated on Prevalence of risk factors for TdP prior to drug initiation. Among patients with psychotropic drug-induced torsade de pointes, 73% had more than two risk factors prior to drug initiation, with female gender being the most common (71.4%).
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