Key result
Drug-induced QT prolongation is a major cause of acquired Torsades de Pointes, necessitating careful prescribing of implicated medications, routine ECG monitoring, and prompt treatment with intravenous magnesium.
Polypharmacy increases the risk of drug interactions that prolong the QTc interval, necessitating caution to prevent torsades de pointes.
Torsades de pointes (TdP) is a specific form of polymorphic ventricular tachycardia, which is a dreadful condition, severity varies from mild asymptomatic condition to severe life threatening state. In this review, i would like to highlight the physiological, pathological and pharmacological causes, prevention and management of torsades de pointes. In this present world of therapeutic jungle, due to wide spread use of medication (poly pharmacy), there is a reasonable chance of getting drug interactions resulting in prolonged QTc interval leading to tosades de pointes. The main aim of this study is to bring awareness about risk of developing torsades de pointes in patients receiving multiple drugs and also to make clinicians and pharmacologists little more cautious while prescribing drugs.
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Thota et al. (2016) conducted a review in Torsades de pointes. QT prolonging drugs was evaluated. Drug-induced QT prolongation is a major cause of acquired Torsades de Pointes, necessitating careful prescribing of implicated medications, routine ECG monitoring, and prompt treatment with intravenous magnesium.
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