Estimation of Instantaneous Oxygen Uptake During Exercise and Daily Activities Using a Wearable Cardio-Electromechanical and Environmental Sensor

Objective: To estimate instantaneous oxygen uptake VO 2 with a small, low-cost wearable sensor during exercise and daily activities in order to enable monitoring of energy expenditure (EE) in uncontrolled settings. We aim to do so using a combination of seismocardiogram (SCG), electrocardiogram (ECG) and atmospheric pressure (AP) signals obtained from a minimally obtrusive wearable device. Methods: In this study, subjects performed a treadmill protocol in a controlled environment and an outside walking protocol in an uncontrolled environment. During testing, the COSMED K5 metabolic system collected gold standard breath-by-breath (B×B) data and a custombuilt wearable patch placed on the mid-sternum collected SCG, ECG and AP signals. We extracted features from these signals to estimate the B×B VO 2 data obtained from the COSMED system. Results: In estimating instantaneous VO 2 , we achieved our best results on the treadmill protocol using a combination of SCG (frequency) and AP features (RMSE of 3.68 ± 0.98 ml/kg/min and R 2 of 0.77). For the outside protocol, we achieved our best results using a combination of SCG (frequency), ECG and AP features (RMSE of 4.3 ± 1.47 ml/kg/min and R 2 of 0.64). In estimating VO 2 consumed over one minute intervals during the protocols, our median percentage error was 15.8% for the treadmill protocol and 20.5% for the outside protocol. Conclusion: SCG, ECG and AP signals from a small wearable patch can enable accurate estimation of instantaneous VO 2 in both controlled and uncontrolled settings. SCG signals capturing variation in cardio-mechanical processes, AP signals, and state of the art machine learning models contribute significantly to the accurate estimation of instantaneous VO 2 . Significance: Accurate estimation of VO 2 with a low cost, minimally obtrusive wearable patch can enable the monitoring of VO 2 and EE in everyday settings and make the many applications of these measurements more accessible to the general public.