Why the study?
Obesity causes conditions such as type 2 diabetes and non-alcoholic fatty liver disease, prompting investigation into the anti-obesity effects of a standardized ethanol extract of Cassia mimosoides var. nomame Makino.
Does standardized ethanol extract of Cassia mimosoides var. nomame Makino reduce body weight gain and adipogenesis in high-fat diet-induced obese mice?
Population
3T3-L1 adipocytes and high-fat diet-fed mice
Comparison
Standardized ethanol extract of Cassia mimosoides var. nomame Makino vs control
Design
In vitro and in vivo preclinical study
Follow-up
10 weeks
Key result
Oral administration of EECM for 10 weeks significantly alleviated body weight gain and body fat accumulation in high-fat diet-fed mice.
Authors
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Hypothesis-generating in murine obesity models; human trials needed before any clinical consideration.
Does standardized ethanol extract of Cassia mimosoides var. nomame Makino reduce body weight gain and adipogenesis in high-fat diet-induced obese mice?
EECM ameliorates obesity by regulating adipogenesis and lipogenesis in preclinical models, suggesting potential as a therapeutic agent for obesity prevention.
Heo et al. (2023) studied Obesity. Standardized ethanol extract of Cassia mimosoides var. nomame Makino (EECM) vs. High-fat diet control was evaluated on Body weight gain and body fat accumulation. Oral administration of EECM for 10 weeks significantly alleviated body weight gain and body fat accumulation in high-fat diet-fed mice.
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