What question did this study set out to answer?

To determine whether absolute myocardial blood flow can be quantified in humans via myocardial contrast echocardiography using a volumetric model of ultrasound contrast agent destruction and refill kinetics.

May 30, 2026Journal of the American College of Cardiology

The quantification of absolute myocardial perfusion in humans by contrast echocardiography

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Coronary artery disease and healthy volunteers (n=35). Intervention: Myocardial contrast echocardiography (MCE) vs. Positron emission tomography (PET) and intracoronary Doppler. Primary outcome: Myocardial blood flow (MBF) quantification.

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Key result

Volumetric MCE closely tracks PET myocardial blood flow with an r2 of ~0.92.

n=35

Why the study?

Does myocardial contrast echocardiography using a volumetric model accurately quantify absolute myocardial blood flow compared to PET and intracoronary Doppler in humans?

Population

20 healthy volunteers and 15 patients with coronary artery disease (coronary stenosis 0% to 89%). Total n=35.

Comparison

Myocardial contrast echocardiography using a… vs Positron emission tomography in healthy…

Design

Cross-sectional

Authors

RVRolf VogelUniversity of Bern AIAndreas IndermühleUniversity of Bern JRJessica S. ReinhardtUniversity of Iowa

Discussion

Member takes

Implication

A volumetric model of ultrasound contrast agent kinetics allows for the noninvasive quantification of absolute myocardial blood flow using myocardial contrast echocardiography, showing strong correlation with PET and intracoronary Doppler.

Key Points

To determine whether absolute myocardial blood flow can be quantified in humans via myocardial contrast echocardiography using a volumetric model of ultrasound contrast agent destruction and refill kinetics.
Tested a volumetric refill model (MBF = rBV · β / ρT) in vitro and in vivo based on relative myocardial blood volume (rBV), exchange frequency (β), and tissue density (ρT).
Compared contrast echocardiography with positron emission tomography in healthy volunteers at rest (group I, n = 15; group II, n = 5) and during adenosine-induced hyperemia (group II).
Evaluated 15 patients with coronary artery disease (stenosis 0% to 89%) comparing contrast echocardiography against simultaneous intracoronary Doppler flow measurements before and during intracoronary adenosine.
In group I healthy volunteers, 187 of 240 myocardial segments were analyzable, demonstrating a strong linear correlation between echocardiography and PET perfusion data at rest (y = 0.899x + 0.079; r² = 0.88).
In group II healthy volunteers, resting and hyperemic perfusion showed close agreement between contrast echocardiography and PET (y = 1.011x + 0.124; r² = 0.92).
In patients with coronary artery disease, myocardial perfusion reserve measured by contrast echocardiography showed good agreement with intracoronary Doppler flow velocity reserve (y = 0.92x + 0.14; r² = 0.73).

Study Design

Type

Observational (n=35)

Structured PICO

Does myocardial contrast echocardiography using a volumetric model accurately quantify absolute myocardial blood flow compared to PET and intracoronary Doppler in humans?

Population

35 participants, including 20 healthy volunteers and 15 patients with coronary artery disease, undergoing myocardial perfusion assessment.

Exposure

Myocardial contrast echocardiography (MCE) using a volumetric model of ultrasound contrast agent kinetics to quantify absolute myocardial blood flow.

Comparator

Positron emission tomography (PET) in healthy volunteers, and intracoronary Doppler measurements in CAD patients.

Outcome

Correlation between MCE-derived myocardial blood flow and reference standards (PET or intracoronary Doppler).surrogate

Cite This Study

Vogel et al. (2005) conducted an observational in Coronary artery disease and healthy volunteers (n=35). Myocardial contrast echocardiography (MCE) vs. Positron emission tomography (PET) and intracoronary Doppler was evaluated on Myocardial blood flow (MBF) quantification. Myocardial contrast echocardiography using a volumetric model showed good agreement with PET for resting and hyperemic perfusion (r2=0.92) and with Doppler for flow velocity reserve (r2=0.73).

synapsesocial.com/papers/6a1affe901492147ba309248 https://doi.org/10.1016/j.jacc.2004.11.044

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The quantification of absolute myocardial perfusion in humans by contrast echocardiography

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

The quantification of absolute myocardial perfusion in humans by contrast echocardiography

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

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