Key result
Elevated admission ET-1 levels predict angiographic no-reflow after successful PCI for AMI.
Why the study?
Elevated systemic ET-1 levels predict poor prognosis in AMI treated by primary PCI, but its relationship with no-reflow was unclear.
Do systemic ET-1 plasma levels predict angiographic no-reflow in patients with a first AMI undergoing successful primary or rescue PCI?
Observational (n=51)
Do systemic ET-1 plasma levels predict angiographic no-reflow in patients with a first AMI undergoing successful primary or rescue PCI?
p-value: p=0.03
Elevated systemic ET-1 plasma levels on admission predict angiographic no-reflow after successful primary or rescue PCI in patients with a first AMI.
No takes yet. Share an insight, caveat, or question.
ET-1 levels may aid no-reflow risk stratification after PCI; hypothesis-generating and should not yet change practice.
Giampaolo Niccoli (2006) conducted an observational in Acute myocardial infarction (AMI) (n=51). Systemic Endothelin-1 (ET-1) plasma levels was evaluated on Angiographic no-reflow (coronary TIMI flow grade ≤2 or TIMI flow 3 with final myocardial blush grade ≤2) (p=0.03). Elevated systemic ET-1 plasma levels on admission independently predicted angiographic no-reflow after successful primary or rescue PCI for acute myocardial infarction (P=0.03).
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