Key result
Mean platelet volume and platelet distribution width were significantly higher in massive pulmonary embolism, with PDW showing high diagnostic value (AUC 0.998, p<0.001).
Why the study?
Massive pulmonary embolism carries high mortality where early diagnosis is vital, prompting evaluation of the diagnostic value of mean platelet volume and platelet distribution width.
Do mean platelet volume and platelet distribution width have diagnostic value for massive pulmonary embolism in emergency care?
Case-Control (n=160)
Do mean platelet volume and platelet distribution width have diagnostic value for massive pulmonary embolism in emergency care?
Mean platelet volume and platelet distribution width are simple, readily available complete blood count parameters that show high diagnostic value for massive pulmonary embolism in the emergency setting.
Answers are grounded in this paper and cite their sources.
May aid rapid PE risk stratification via routine CBC in emergencies; leaves open prospective validation before practice change.
Objectives: Massive pulmonary embolism is a life-threatening condition mostly seen in the emergency setting.Early diagnosis and treatment decrease the risk of mortality.Apart from imaging tests, increased blood levels of several parameters were shown to be helpful to identify these patients.We aimed to determine the diagnostic value of mean platelet volume and platelet distribution width for the diagnosis of acute massive pulmonary embolism. Materials and Methods:We retrospectively reviewed the medical records of patients who were admitted to the emergency department from January 2012 to January 2016.Patients who had a diagnosis of massive pulmonary embolism confirmed by computed tomography pulmonary angiography were included.Blood samples were drawn at admission.Transthoracic echocardiography was performed to evaluate right ventricular size and function.Age and sex matched patients who were admitted to the emergency department with any diagnosis other than pulmonary embolism were enrolled as a control group.Results: Eighty patients met the inclusion criteria and age and sex matched 80 patients were enrolled as a control group.The mean platelet volume and platelet distribution width were significantly higher in patients with massive pulmonary embolism compared to control group [10.1±0.1 fL vs 7.9±0.1 fL p<0.001, 17 (15.5-18.8)vs 13.6 (12.3-15.9)p<0.001 respectively].Platelet distribution width had the most powerful diagnostic value among other parameters including the mean platelet volume, D-dimer and pro-BNP (area under the curve=0.998,p<0.001). Conclusion:Massive pulmonary embolism is a thromboembolic disease associated with high mortality.Platelet distribution width and mean platelet volume are simple parameters of complete blood count that can be used to increase predictive value of previously validated tests when used concomitantly.They may also help to select patients who will undergo imaging.
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Oğuz et al. (2023) conducted a case-control in Massive pulmonary embolism (n=160). Mean platelet volume and platelet distribution width vs. Age and sex matched patients with diagnoses other than pulmonary embolism was evaluated on Diagnosis of acute massive pulmonary embolism (AUC 0.998, p=<0.001). Mean platelet volume and platelet distribution width were significantly higher in massive pulmonary embolism, with PDW showing high diagnostic value (AUC 0.998, p<0.001).
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