Key result
Mean platelet volume was significantly higher in pulmonary embolism patients who died during the early hospital period compared to those who survived (9.08 fL vs 7.85 fL, p=0.01).
Why the study?
Is mean platelet volume (MPV) associated with early hospital mortality in patients with pulmonary embolism?
Observational (n=143)
No
Is mean platelet volume (MPV) associated with early hospital mortality in patients with pulmonary embolism?
Absolute Event Rate: 9.08% vs 7.85%
p-value: p=0.01
Increased mean platelet volume (MPV) may serve as a simple, accessible biomarker for predicting early hospital mortality in patients with pulmonary embolism.
May aid early risk stratification in PE; hypothesis-generating and requires prospective validation.
Objective: In this study whether mean platelet volume (MPV) is associated with early period hospital mortality or not in patients with pulmonary embolism (PE) was investigated. Methods: Data of patients that hospitalized in chest diseases clinic with the diagnosis of PE between the years 2009-2012 were screened retrospectively from digital archive system. The demographic data, symptoms, treatment outcomes and MPV values in complete blood count of patients were recorded. Results: The mean age was 57.93 ± 18.52 years (16-91). The number of patients is 143 and 91 women (63.9%), 52 men (36.4%), respectively. MPV values were available for 137 of 143 patients. 129 of patients were discharged, and 8 had died in the early period of hospitalization. The mean MPV value was 7.85 ± 1.40 fL in patients who experienced and 9.08 ± 1.61 fL in died respectively. The difference was statistically significant (p = 0.01). Conclusion: The results of this study suggests that increased MPV value may be used as a marker for early hospital mortality in patients with PE.
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Şen et al. (2013) conducted an observational in Pulmonary embolism (n=143). Mean platelet volume (MPV) vs. Survivors (patients discharged) was evaluated on Mean platelet volume in patients who died during early hospitalization vs those who survived (p=0.01). Mean platelet volume was significantly higher in pulmonary embolism patients who died during the early hospital period compared to those who survived (9.08 fL vs 7.85 fL, p=0.01).
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