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August 22, 2011Scandinavian Journal of Clinical and Laboratory Investigation

Mean platelet volume in predicting short- and long-term morbidity and mortality in patients with or without ST-segment elevation myocardial infarction

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Key result

Elevated mean platelet volume (>11.1 fL) independently predicted two-year mortality in patients with acute myocardial infarction (12.5% vs 9.9%; HR 1.7; 95% CI 1.5-1.9; p<0.001).

Why the study?

Does elevated mean platelet volume predict in-hospital and two-year mortality in patients with acute myocardial infarction?

Population

429 patients with acute myocardial infarction, including 279 with STEMI and 150 with NSTEMI, mean age 61.9 ±…

Comparison

Elevated Mean Platelet Volume (MPV >11.1 fL) vs Lower Mean Platelet Volume (MPV <11.1 fL)

Design

Cohort

Follow-up

Two years

Authors

ETEbru TekbaşAKAli Fuad KaraZAZuhal Arıtürk

Discussion

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Member takes

Overview

May support MPV in AMI risk stratification; leaves open prospective validation of incremental value.

Study Design

Type

Observational (n=429)

Structured PICO

Does elevated mean platelet volume predict in-hospital and two-year mortality in patients with acute myocardial infarction?

P
Population
429 patients with acute myocardial infarction (AMI), including 279 with STEMI and 150 with NSTEMI, mean age 61.9 ± 12.4 years, 70.4% male.
I
Intervention
Elevated Mean Platelet Volume (MPV >11.1 fL)
C
Comparator
Lower Mean Platelet Volume (MPV <11.1 fL)
O
Outcome
In-hospital mortality and two-year mortalityhard clinical

Main Result

Effect estimate: Hazard ratio 1.7 (95% CI 1.5-1.9)

Absolute Event Rate: 12.5% vs 9.9%

p-value: p=<0.001

Elevated mean platelet volume is an independent predictor of in-hospital mortality in STEMI patients and two-year mortality in all AMI patients.

Cite This Study

Tekbaş et al. (2011) conducted an observational in Acute myocardial infarction (STEMI and NSTEMI) (n=429). Elevated mean platelet volume (>11.1 fL) vs. Mean platelet volume <11.1 fL was evaluated on Two-year mortality (Hazard ratio 1.7, 95% CI 1.5-1.9, p=<0.001). Elevated mean platelet volume (>11.1 fL) independently predicted two-year mortality in patients with acute myocardial infarction (12.5% vs 9.9%; HR 1.7; 95% CI 1.5-1.9; p<0.001).

synapsesocial.com/papers/6a05009c22c8a0113de45d4fhttps://doi.org/10.3109/00365513.2011.599416
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic implications of mean platelet volume on short- and long-term outcomes among patients with non-ST-segment elevation myocardial infarction treated with percutaneous coronary intervention: A single-center large observational study2016 · 47 citations
  2. 2Impact of Mean Platelet Volume on Long-Term Mortality in Chinese Patients with ST-Elevation Myocardial Infarction2016 · 18 citations
  3. 3The Prognostic Impact of In-Hospital Change in Mean Platelet Volume in Patients With Non–ST-Segment Elevation Myocardial Infarction2016 · 16 citations
  4. 4Mean Platelet Volume and Its Association With In-Hospital Outcomes in Patients With Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention2024 · 1 citations
  5. 5Mean platelet volume is associated with infarct size and microvascular obstruction estimated by cardiac magnetic resonance in ST segment elevation myocardial infarction2013 · 22 citations