Elevated mean platelet volume (>11.1 fL) independently predicted two-year mortality in patients with acute myocardial infarction (12.5% vs 9.9%; HR 1.7; 95% CI 1.5-1.9; p<0.001).
Observational (n=429)
Does elevated mean platelet volume predict in-hospital and two-year mortality in patients with acute myocardial infarction?
Elevated mean platelet volume is an independent predictor of in-hospital mortality in STEMI patients and two-year mortality in all AMI patients.
Effect estimate: Hazard ratio 1.7 (95% CI 1.5-1.9)
Absolute Event Rate: 12.5% vs 9.9%
p-value: p=<0.001
Mean platelet volume (MPV) is a marker of platelet activation. An increased MPV is associated with acute myocardial infarction (AMI) and long-term mortality. The aim of this study was to compare MPV in patients with ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI). Also, we investigated the value of MPV on in-hospital mortality and long-term prognosis of patients with STEMI and NSTEMI. We studied 429 patients with AMI (70.4% male, 61.9 ± 12.4 years; 279 patients with STEMI, 150 patients with NSTEMI). MPV and platelet count were similar in both groups. Elevated MPV increased the risk of death by 3.1-fold (p 11.1 fL versus 9.9% in patients with MPV <11.1 fL (p < 0.001). Cox regression analysis showed MPV to be an independent predictor of two-year mortality (Hazard ratio 1.7; 95% CI 1.5-1.9; p < 0.001). An increased MPV is an independent predictor of in-hospital mortality in patients with STEMI. However, elevated levels of MPV did not predict in hospital mortality in NSTEMI group. The increase in MPV values was independently correlated with two-year mortality in all study patients.
Tekbaş et al. (Mon,) conducted a observational in Acute myocardial infarction (STEMI and NSTEMI) (n=429). Elevated mean platelet volume (>11.1 fL) vs. Mean platelet volume <11.1 fL was evaluated on Two-year mortality (Hazard ratio 1.7, 95% CI 1.5-1.9, p=<0.001). Elevated mean platelet volume (>11.1 fL) independently predicted two-year mortality in patients with acute myocardial infarction (12.5% vs 9.9%; HR 1.7; 95% CI 1.5-1.9; p<0.001).