Key result
High mean platelet volume in STEMI patients was associated with larger infarct size (17.6% vs 12.5%; P=0.021) and increased risk of major adverse cardiac events (HR 3.35; 95% CI 1.1-9.9; P=0.03).
Why the study?
Is high mean platelet volume associated with larger infarct size and microvascular obstruction in patients with first STEMI?
Population
128 patients diagnosed with first STEMI successfully reperfused during three consecutive years
Comparison
High mean platelet volume measured on admission vs Low mean platelet volume (lower two tertiles)
Design
Cohort
Follow-up
1 year
Authors
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High mean platelet volume on admission in patients with first STEMI is associated with larger infarct size, microvascular obstruction, and increased risk of major adverse cardiac events at 1 year.
Cohort (n=128)
Is high mean platelet volume associated with larger infarct size and microvascular obstruction in patients with first STEMI?
Absolute Event Rate: 17.6% vs 12.5%
p-value: p=0.021
High mean platelet volume on admission in patients with first STEMI is associated with larger infarct size, microvascular obstruction, and increased risk of major adverse cardiac events at 1 year.
Fabregat‐Andrés et al. (2013) conducted a cohort in ST-segment elevation myocardial infarction (STEMI) (n=128). High mean platelet volume (≥9.5 fl) vs. Low mean platelet volume (<9.5 fl) was evaluated on Infarct size (percentage of necrosis by LGE) (p=0.021). High mean platelet volume in STEMI patients was associated with larger infarct size (17.6% vs 12.5%; P=0.021) and increased risk of major adverse cardiac events (HR 3.35; 95% CI 1.1-9.9; P=0.03).
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