Key result
High mean platelet volume in STEMI patients was associated with larger infarct size and increased risk of major adverse cardiac events.
Why the study?
Is high mean platelet volume associated with larger infarct size and microvascular obstruction in patients with first STEMI?
Cohort (n=128)
Is high mean platelet volume associated with larger infarct size and microvascular obstruction in patients with first STEMI?
Answers are grounded in this paper and cite their sources.
High mean platelet volume on admission in patients with first STEMI is associated with larger infarct size, microvascular obstruction, and increased risk of major adverse cardiac events at 1 year.
Mean platelet volume (MPV) is an indicator of platelet activation. High MPV has been recently considered as an independent risk factor for poor outcomes after ST-segment elevation myocardial infarction (STEMI). We analyzed 128 patients diagnosed with first STEMI successfully reperfused during three consecutive years. MPV was measured on admission and a cardiac magnetic resonance (CMR) exam was performed within the first week in all patients. Myocardial necrosis size was estimated by the area of late gadolinium enhancement (LGE), identifying microvascular obstruction (MVO), if present. Clinical outcomes were recorded at 1 year follow-up. High MPV was defined as a value in the third tertile (≥9.5 fl), and a low MPV, as a value in the lower two. We found a slight but significant correlation between MPV and infarct size (r = 0.287, P = 0.008). Patients with high MPV had more extensive infarcted area (percentage of necrosis by LGE: 17.6 vs. 12.5%, P = 0.021) and more presence of MVO (patients with MVO pattern: 44.4 vs. 25.3%, P = 0.027). In a multivariable analysis, hazard ratio for major adverse cardiac events was 3.35 [95% confidence interval (CI) 1.1-9.9, P = 0.03] in patients with high MPV. High MPV in patients with first STEMI is associated with higher infarct size and more presence of MVO measured by CMR.
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Fabregat‐Andrés et al. (2013) conducted a cohort in ST-segment elevation myocardial infarction (STEMI) (n=128). High mean platelet volume (≥9.5 fl) vs. Low mean platelet volume (<9.5 fl) was evaluated on Infarct size (percentage of necrosis by LGE) (p=0.021). High mean platelet volume in STEMI patients was associated with larger infarct size and increased risk of major adverse cardiac events.
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