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November 29, 2020Medical Laboratory Technology JournalOpen Access

Increased Mean Platelet Volume (MPV) in Patients with ST Elevation Myocardial Infarction (STEMI) Compared to Non-ST Elevation Myocardial Infarction (NSTEMI) Patients

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Key result

Mean Platelet Volume was higher in patients with STEMI (9.38 fL) compared to NSTEMI (8.52 fL), but this difference was not statistically significant (p=0.091).

Why the study?

Increased mean platelet volume reflects larger, more reactive platelets that accelerate intracoronary thrombus formation, prompting evaluation of its increase in STEMI and NSTEMI to aid diagnosis and treatment decisions.

Is Mean Platelet Volume (MPV) higher in patients with STEMI compared to NSTEMI?

Comparison

STEMI vs NSTEMI

Design

Analytic observational cross-sectional study

Authors

TRTri RatnaningsihIIIstiqomah Istiqomah

Discussion

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Member takes

Overview

Elevated MPV was associated with ACS; hypothesis-generating and should not yet change practice.

Study Design

Type

Cross-Sectional (n=34)

Multicenter

No

Structured PICO

Is Mean Platelet Volume (MPV) higher in patients with STEMI compared to NSTEMI?

P
Population
34 adults aged 30-70 years with acute coronary syndrome (STEMI or NSTEMI) within 48 hours of onset, evaluated in a cross-sectional study.
O
Outcome
Mean Platelet Volume (MPV)surrogate

Main Result

Absolute Event Rate: 9.38% vs 8.52%

p-value: p=0.091

Mean platelet volume tends to be higher in STEMI compared to NSTEMI patients, though the difference did not reach statistical significance in this small cohort.

Limitations

  • Insufficient number of subjects
  • Did not analyze the level of depression in subjects, which may independently influence platelet activity and increase MPV
  • insufficient number of subjects
  • did not analyze the level of depression in subjects

Cite This Study

Ratnaningsih et al. (2020) conducted a cross-sectional in Acute Coronary Syndromes (STEMI and NSTEMI) (n=34). ST-segment Elevation Myocardial Infarction (STEMI) vs. Non-ST-segment Elevation Myocardial Infarction (NSTEMI) was evaluated on Mean Platelet Volume (MPV) (p=0.091). Mean Platelet Volume was higher in patients with STEMI (9.38 fL) compared to NSTEMI (8.52 fL), but this difference was not statistically significant (p=0.091).

synapsesocial.com/papers/6aa03d31d2043063d7e6ba2dhttps://doi.org/10.31964/mltj.v6i2.320
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mean platelet volume in predicting short- and long-term morbidity and mortality in patients with or without ST-segment elevation myocardial infarction2011 · 42 citations
  2. 2Comparison of Mean Platelet Volume at Admission in Subtypes of Acute Myocardial Infarction2019
  3. 3Prognostic implications of mean platelet volume on short- and long-term outcomes among patients with non-ST-segment elevation myocardial infarction treated with percutaneous coronary intervention: A single-center large observational study2016 · 47 citations
  4. 4Mean platelet volume is associated with infarct size and microvascular obstruction estimated by cardiac magnetic resonance in ST segment elevation myocardial infarction2013 · 22 citations
  5. 5Mean Platelet Volume and Its Association With In-Hospital Outcomes in Patients With Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention2024 · 2 citations