Key result
An early increase in mean platelet volume after admission was independently associated with total mortality at 1 year in patients with NSTEMI.
Why the study?
Does an early increase in mean platelet volume predict total mortality in patients with NSTEMI?
Cohort (n=400)
Does an early increase in mean platelet volume predict total mortality in patients with NSTEMI?
An early increase in mean platelet volume within 24 hours of admission is an independent predictor of 1-year mortality in patients with NSTEMI, suggesting these patients may require more intensive antiplatelet therapy.
Answers are grounded in this paper and cite their sources.
MPV change may predict NSTEMI mortality; hypothesis-generating and requires prospective validation before clinical use.
It is unclear whether changes in mean platelet volume (MPV) are associated with total mortality in acute coronary syndromes. We investigated whether the change in MPV predicts total mortality in patients with non-ST-segment elevation myocardial infarction (NSTEMI). We retrospectively analyzed 419 consecutive patients (19 patients were excluded). The remaining patients were categorized as survivors (n = 351) or nonsurvivors (n = 49). Measurements of MPV were performed at admission and after 24 hours. The difference between the 2 measurements was considered as the MPV change (ΔMPV). The end point of the study was total mortality at 1-year follow-up. During the follow-up, there were 49 deaths (12.2%). Admission MPV was comparable in the 2 groups. However, both MPV (9.6 ± 1.4 fL vs 9.2 ± 1.0 fL, P = .044) and ΔMPV (0.40 [0.10-0.70] fL vs 0.70 [0.40-1.20] fL, P < .001) at the first 24 hours were higher in nonsurvivors than survivors. In multivariate analysis, ΔMPV was an independent predictor of total mortality (odds ratio: 1.84, 95% confidence interval: 1.28-2.65, P = .001). An early increase in MPV after admission was independently associated with total mortality in patients with NSTEMI. Such patients may need more effective antiplatelet therapy.
No takes yet. Share an insight, caveat, or question.
Kırış et al. (2016) conducted a cohort in Non-ST-segment elevation myocardial infarction (NSTEMI) (n=400). Change in mean platelet volume (ΔMPV) was evaluated on Total mortality at 1-year follow-up (OR 1.84, 95% CI 1.28-2.65, p=0.001). An early increase in mean platelet volume after admission was independently associated with total mortality at 1 year in patients with NSTEMI.
Synapse has enriched 10 related papers. Consider them for comparative context: