January 1, 2011Thrombosis and Haemostasis
Prognostic significance of mean platelet volume on admission in an unselected cohort of patients with non ST-segment elevation acute coronary syndrome
Key result
Elevated mean platelet volume on admission (≥8.9 fl) was independently associated with a higher risk of cardiovascular death and re-MI at one year (HR 1.41; 95% CI 1.06-1.89; p=0.02).
Why the study?
Does elevated mean platelet volume on admission predict cardiovascular death and re-MI in patients with NSTE-ACS?
Population
1,041 consecutive patients with non-ST elevation acute coronary syndrome (NSTE-ACS)
Comparison
Elevated mean platelet volume on admission vs Lower mean platelet volume on admission
Design
Cohort
Follow-up
one year
Authors
Discussion
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Member takes
Implication
Elevated mean platelet volume on admission independently predicts a higher risk of cardiovascular death and re-MI at one year in patients with NSTE-ACS.
Study Design
Type
Cohort (n=1,041)
Structured PICO
Does elevated mean platelet volume on admission predict cardiovascular death and re-MI in patients with NSTE-ACS?
P
Population
1,041 consecutive patients with non-ST elevation acute coronary syndrome (NSTE-ACS)
I
Intervention
Elevated mean platelet volume (MPV) on admission (highest quartile Q4 ≥8.9 fl)
C
Comparator
Lower mean platelet volume (MPV) on admission (quartiles Q1-Q3 <8.9 fl)
O
Outcome
Composite of cardiovascular death and re-myocardial infarction (MI) at one yearcomposite
Main Result
Effect estimate: HR 1.41 (95% CI 1.06-1.89)
p-value: p=0.02
Elevated mean platelet volume on admission independently predicts a higher risk of cardiovascular death and re-MI at one year in patients with NSTE-ACS.
Cite This Study
Saia et al. (2011) conducted a cohort in non-ST elevation acute coronary syndrome (NSTE-ACS) (n=1,041). Elevated mean platelet volume (MPV ≥8.9 fl) vs. Lower mean platelet volume (MPV <8.9 fl) was evaluated on Composite of cardiovascular death and re-myocardial infarction (MI) at one year (HR 1.41, 95% CI 1.06-1.89, p=0.02). Elevated mean platelet volume on admission (≥8.9 fl) was independently associated with a higher risk of cardiovascular death and re-MI at one year (HR 1.41; 95% CI 1.06-1.89; p=0.02).