Key result
An elevated mean platelet volume was associated with an increased risk of long-term all-cause mortality compared to a normal volume in Chinese patients with STEMI.
Why the study?
Is mean platelet volume associated with all-cause mortality in Chinese patients with STEMI?
Cohort (n=1,836)
No
Is mean platelet volume associated with all-cause mortality in Chinese patients with STEMI?
Answers are grounded in this paper and cite their sources.
Increased mean platelet volume is associated with higher long-term all-cause mortality in Chinese patients with STEMI, suggesting its utility as a risk stratification marker.
We investigated the association between mean platelet volume (MPV) and risk of all-cause mortality in Chinese patients with ST-Elevation Myocardial Infarction (STEMI). We enrolled 1836 patients with STEMI in Xuanwu Hospital from January 2008 to December 2013. Based on MPV, patients were categorized into the following groups: < 9.5 fL (n = 85), 9.5-11.0 fL (n = 776), 11.1-12.5 fL (n = 811) and >12.5 fL (n = 164), respectively. Mean duration of follow-up was 56.9 months, and 197 patients (10.7%) died during follow-up. All-cause mortality rates were compared between groups. The lowest mortality occurred in patients with MPV between 9.5-11.0 fL, with a multivariable-adjusted hazard ratio (HR) of 1.15(95%CI 0.62-1.50), 1.38(95%CI 1.20-1.68), and 1.72(95%CI 1.41-1.96) in patients with MPV of <.5, 11.1-12.5 and >12.5 fL, respectively. Therefore, increased MPV was associated with all-cause mortality in Chinese patients with STEMI. MPV might be useful as a marker for risk stratification in Chinese patients with STEMI.
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Sun et al. (2016) conducted a cohort in ST-Elevation Myocardial Infarction (STEMI) (n=1,836). Elevated Mean Platelet Volume (>12.5 fL) vs. Normal Mean Platelet Volume (9.5-11.0 fL) was evaluated on All-cause mortality (HR 1.72, 95% CI 1.41-1.96, p=0.004). An elevated mean platelet volume was associated with an increased risk of long-term all-cause mortality compared to a normal volume in Chinese patients with STEMI.
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