Key result
Higher central arterial stiffness is linked to lower ICA diastolic velocity, mediating age-related CBF decline.
Why the study?
Does higher central arterial stiffness mediate lower cerebral blood flow with age via lower diastolic velocity of the internal carotid artery?
Does higher central arterial stiffness mediate lower cerebral blood flow with age via lower diastolic velocity of the internal carotid artery?
Higher central arterial stiffness is associated with lower diastolic velocity of the internal carotid artery, providing a mechanism for age-related reductions in cerebral blood flow.
Answers are grounded in this paper and cite their sources.
Should not yet change practice; extends observational links but leaves causal role in cerebral blood flow open.
In this study, we demonstrated that higher central arterial stiffness is associated with lower diastolic velocity of the ICA, which mediates lower CBF with age. These findings provide new mechanistic insights into the reduction in CBF with age and add to the mounting evidence for the importance of age-related central arterial stiffening in brain health.
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Ashley et al. (2025) studied this question. Higher central arterial stiffness is associated with lower diastolic velocity in the internal carotid artery, which mediates the age-related reduction in cerebral blood flow.
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