Why the study?
Do peak systolic velocities in the internal carotid artery correlate with cerebral blood flow deficits in elderly men with mild carotid stenosis (<50%)?
Do peak systolic velocities in the internal carotid artery correlate with cerebral blood flow deficits in elderly men with mild carotid stenosis (<50%)?
In elderly men with mild asymptomatic carotid stenosis (<50%), higher peak systolic velocities correlate with reduced cerebral blood flow, suggesting these patients may benefit from intensified pharmacotherapy to prevent cerebrovascular events.
Higher ICA velocities were associated with lower cerebral blood flow in mild stenosis; hypothesis-generating and should not yet change practice.
To examine if mild carotid stenosis correlates with silent vascular brain changes, we studied a prospective population-based cohort "Men born in 1914." Data from followups at ages 68 and 81, have been used. Carotid ultrasound was performed at age 81, and cerebral blood flow (CBF) was measured with SPECT at age 82. Out of 123 stroke-free patients, carotid stenosis <50% was observed in 94% in the right and 89% in the left internal carotid arteries (ICAs). In these subjects, Peak Systolic Velocities in ICA correlated negatively with CBF in a majority of several brain areas, especially in mesial temporal area. Results were limited to normotensive until their seventies, who developed late-onset hypertension with a subsequent blood pressure, pulse pressure, and ankle-brachial index growth. Elderly with asymptomatic carotid stenosis <50% and peak systolic velocities in ICA 0.7-1.3 m/s, should be offered an intensified pharmacotherapy to prevent stroke or silent cerebrovascular events.
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Siennicki‐Lantz et al. (2012) studied this question.
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