Key result
NOACs show better efficacy and safety than traditional therapies for NVAF and VTE in Japanese patients.
Why the study?
Clinical decision-making with anticoagulants requires considering differences between trial populations and actual clinical practice as well as historical backgrounds.
This review summarizes recent real-world evidence confirming the efficacy and safety of non-vitamin K oral anticoagulants in Japanese patients with non-valvular atrial fibrillation and venous thromboembolism.
Answers are grounded in this paper and cite their sources.
Supports NOAC preference in Japanese NVAF/VTE patients; leaves open practice changes pending prospective randomized confirmation.
Anticoagulant therapy is a drug therapy that inhibits the formation of blood clots. Although anticoagulants are effective in preventing thromboembolism, they also carry the risk of bleeding, so they must be managed carefully, taking both efficacy and safety into account. Evidence regarding the effectiveness and safety of each anticoagulant has already accumulated through many large clinical trials and post-marketing surveillance. However, when making decisions in clinical practice, it is necessary to always take into consideration differences in patient populations between clinical trials and actual clinical practice, as well as differences in historical background. (For example, there are differences in antiplatelet drugs and coronary artery interventions that were mainly used in each era.) In this review we discuss the effectiveness and safety of currently used anticoagulants, focusing on different patient backgrounds and points to keep in mind regarding their proper use, based on the latest reports in Asian populations, especially Japanese people, over the past 1-2 years.
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Hara et al. (2024) conducted a review in Non-valvular atrial fibrillation and venous thromboembolism. Oral Anticoagulants (NOACs) vs. Warfarin was evaluated. Novel oral anticoagulants demonstrate preferable efficacy and safety compared to traditional therapies for the management of non-valvular atrial fibrillation and venous thromboembolism in Japanese patients.
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