Key result
Low baseline haptoglobin is linked to post-PFA increases, whereas higher levels show postprocedural depletion.
Why the study?
Does having a very low baseline haptoglobin level (≤5 mg/dL) alter postprocedural haptoglobin responses in patients undergoing pulsed field ablation?
Cohort (n=421)
No
Does having a very low baseline haptoglobin level (≤5 mg/dL) alter postprocedural haptoglobin responses in patients undergoing pulsed field ablation?
In patients undergoing pulsed field ablation, very low but measurable baseline haptoglobin levels (≤5 mg/dL) are paradoxically associated with postprocedural haptoglobin increases rather than the depletion seen in patients with higher baseline levels.
Answers are grounded in this paper and cite their sources.
Baseline haptoglobin may guide hemolysis monitoring after pulsed field ablation; extends renal injury associations but leaves open prospective validation.
Background: Low baseline haptoglobin (Hpt) levels have been associated with renal injury after pulsed field ablation (PFA). Postprocedural Hpt responses in patients with very low but measurable baseline Hpt levels remain unknown. Methods and Results: We retrospectively analyzed 421 patients undergoing PFA. Patients with baseline Hpt ≤5 mg/dL showed postprocedural Hpt increases, whereas those with higher baseline Hpt showed depletion (P<0.001). Acute kidney injury occurred in 9 patients in the overall cohort. Conclusions: Very low but measurable baseline Hpt levels were associated with postprocedural increases in Hpt, warranting further investigation.
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Chikata et al. (2026) conducted a cohort in Arrhythmia undergoing pulsed field ablation (PFA) (n=421). Very low baseline haptoglobin (≤5 mg/dL) in pulsed field ablation vs. Higher baseline haptoglobin (6–40 mg/dL and >40 mg/dL) was evaluated on Postprocedural haptoglobin ratio (day 1 / baseline) (p=<0.001). Baseline haptoglobin ≤5 mg/dL was associated with postprocedural haptoglobin increases after pulsed field ablation, whereas baseline levels >5 mg/dL showed depletion (P<0.001).
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