Why the study?
Does antilymphocyte serum improve survival times in Swiss albino mice infected with Langat virus?
Does antilymphocyte serum improve survival times in Swiss albino mice infected with Langat virus?
Antilymphocyte serum prolongs survival in mice with viral encephalitis, suggesting a role for cell-mediated immune responses and potential autoimmunity in the disease process.
Hypothesis-generating for cell-mediated immunity in viral encephalitis; leaves open translation to human disease.
Antilymphocyte serum given to suppress selectively the cell response to Langat virus in Swiss albino mice prolonged the average survival times. In vitro, lymph-node cells from virus-immunized mice were strongly cytotoxic for syngenic non-neuronal brain cells infected with virus. The implications of these findings are discussed, with particular reference to the concept of autoimmunity.
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Rook et al. (1970) studied this question.
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