April 1, 1989The Journal of Immunology

Characterization of the inflammatory response in the central nervous system of mice susceptible or resistant to demyelination by Theiler's virus.

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Population

Mice susceptible or resistant to demyelination by Theiler's murine encephalomyelitis virus

Comparison

Intracerebral inoculation with Theiler's murine… vs Comparison between susceptible and resistant…

Design

Preclinical

Follow-up

up to 27 days post-infection

Authors

MLMark D. LindsleyCenters for Disease Control and Prevention MRMoses RodriguezFlorida State University

Discussion

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Implication

May implicate Lyt-2+ kinetics in viral demyelination susceptibility; leaves open human translation and therapeutic targeting.

Structured PICO

Population

Mice susceptible (SJL/J) or resistant (C57BL/10SNJ) to demyelination by Theiler's murine encephalomyelitis virus

Intervention

Intracerebral inoculation with Theiler's murine encephalomyelitis virus

Comparator

Comparison between susceptible (SJL/J) and resistant (C57BL/10SNJ) strains

Outcome

Characterization of the inflammatory response (mononuclear leukocytes, T cell subsets) in the central nervous systemsurrogate

Lyt-2+ lymphocytes appear to play an important role in the mechanism of susceptibility or resistance to Theiler's virus-induced demyelination in mice.

Cite This Study

Lindsley et al. (1989) studied this question.

synapsesocial.com/papers/6a905dde4aebf474cb341ddc https://doi.org/10.4049/jimmunol.142.8.2677

View Full Paper

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Characterization of the inflammatory response in the central nervous system of mice susceptible or resistant to demyelination by Theiler's virus.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of the inflammatory response in the central nervous system of mice susceptible or resistant to demyelination by Theiler's virus.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider