Population
CD4- and CD8-deficient B6, PLJ, and SJL mice infected intracerebrally with Theiler's murine…
Comparison
Genetic deletion of CD4 or CD8 vs Wild-type mice (implied)
Design
Preclinical
Follow-up
chronic stage of disease
Authors
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Supports nonredundant CD4+/CD8+ roles in murine viral demyelination; leaves open translation to human disease and requires validation.
CD4+ and CD8+ T cells make discrete and nonredundant contributions to protection from viral persistence and demyelination in resistant mice, while in susceptible strains, CD8+ T cells do not protect against chronic demyelinating disease.
Murray et al. (1998) studied this question.
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