October 15, 2001The FASEB Journal

Preservation of motor function by inhibition of CD8+ virus peptide‐specific T cells in Theiler's virus infection

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Population

C57BL/6 and Interferon-g (IFN-g)R-/- mice infected with Theiler's murine encephalomyelitis virus (TMEV)

Design

Preclinical

Follow-up

6 weeks

Authors

AJAaron J. JohnsonMayo Clinic JUJadee L. UpshawMayo Clinic KPKevin D. PavelkoMayo Clinic

Discussion

Member takes

Implication

Hypothesis-generating for CD8+ T cell-targeted therapy in viral MS models; requires validation before human translation.

Structured PICO

Population

C57BL/6 and Interferon-g (IFN-g)R-/- mice infected with Theiler's murine encephalomyelitis virus (TMEV)

Intervention

Administration of VP2121-130 peptide before and during TMEV infection

Outcome

Motor dysfunction and demyelinationsurrogate

Inhibition of virus-specific CD8+ T cells preserves motor function in a chronic-progressive viral model of multiple sclerosis, demonstrating their contribution to neurological injury.

Cite This Study

Johnson et al. (2001) studied this question.

synapsesocial.com/papers/6a905e5bd68f3313dd8419e5 https://doi.org/10.1096/fj.01-0373fje

View Full Paper

Ask AI

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Preservation of motor function by inhibition of CD8+ virus peptide‐specific T cells in Theiler's virus infection

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Preservation of motor function by inhibition of CD8+ virus peptide‐specific T cells in Theiler's virus infection

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider