November 1, 1994The Journal of Immunology

A predominant viral epitope recognized by T cells from the periphery and demyelinating lesions of SJL/J mice infected with Theiler's virus is located within VP1233-244.

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Population

SJL/J mice infected with or immunized against Theiler's murine encephalomyelitis virus

Design

Preclinical

Authors

RYRobert L. YauchGene Therapy Laboratory BKB S KimNorthwestern University

Discussion

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Implication

Identifies a candidate epitope in TMEV demyelination models; leaves open relevance to human multiple sclerosis.

Structured PICO

Population

SJL/J mice (demyelination-susceptible) infected with or immunized against Theiler's murine encephalomyelitis virus (TMEV)

Intervention

Epitope mapping using fusion proteins and synthetic peptides of the VP1 capsid protein

Outcome

Identification of the fine specificity of the T cell responsesurrogate

A specific T cell response against the VP1(233-244) epitope is involved in the pathogenesis of TMEV-induced demyelinating disease, a murine model for multiple sclerosis.

Cite This Study

Yauch et al. (1994) studied this question.

synapsesocial.com/papers/6a8d2e9d0b453ccb7788de32 https://doi.org/10.4049/jimmunol.153.10.4508

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A predominant viral epitope recognized by T cells from the periphery and demyelinating lesions of SJL/J mice infected with Theiler's virus is located within VP1233-244.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A predominant viral epitope recognized by T cells from the periphery and demyelinating lesions of SJL/J mice infected with Theiler's virus is located within VP1233-244.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider