November 1, 1995Journal of VirologyOpen Access

Identification of a major T-cell epitope within VP3 amino acid residues 24 to 37 of Theiler's virus in demyelination-susceptible SJL/J mice

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Population

Demyelination-susceptible SJL/J mice

Design

Preclinical

Authors

Discussion

Targets predominant Th-cell epitope for mechanistic TMEV studies; leaves open translation to human demyelinating disease or therapy.

Population

Demyelination-susceptible SJL/J mice

Intervention

Intracerebral inoculation or immunization with Theiler's murine encephalomyelitis virus (TMEV)

Outcome

Identification of T-cell epitopes recognized by T lymphocytessurrogate

Identifies a major T-cell epitope (VP3 24-37) in TMEV that drives the Th-cell response in a murine model of virus-induced demyelinating disease.

Yauch et al. (1995) studied this question.

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