April 1, 1991The Journal of Immunology

Class II-restricted T cell responses in Theiler’s murine encephalomyelitis virus-induced demyelinating disease. IV. Identification of an immunodominant T cell determinant on the N-terminal end of the VP2 capsid protein in susceptible SJL/J mice

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Population

TMEV-susceptible SJL/J and TMEV-resistant C57BL/6 mouse strains

Comparison

TMEV infection and immunization vs Comparison between susceptible and resistant…

Design

Preclinical

Authors

SGS J GeretyNorthwestern University RCRichard J. ClatchHighland Hospital HLHoward L. LiptonUniversity of Illinois Chicago

Discussion

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Implication

Hypothesis-generating for VP2-targeted immunomodulation in TMEV demyelination; human studies needed before clinical adoption.

Structured PICO

Population

TMEV-susceptible SJL/J and TMEV-resistant C57BL/6 mouse strains

Intervention

TMEV infection and immunization

Comparator

Comparison between susceptible and resistant strains, and between different capsid proteins (VP1, VP2, VP3)

Outcome

T cell-mediated responses (DTH and Tprlf) specificitysurrogate

Identification of an immunodominant T cell determinant on the VP2 capsid protein in TMEV-susceptible SJL/J mice provides a potential target for specific immunoregulatory processes in demyelinating disease.

Cite This Study

Gerety et al. (1991) studied this question.

synapsesocial.com/papers/6a7218db26770c2b8de15508 https://doi.org/10.4049/jimmunol.146.7.2401

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Class II-restricted T cell responses in Theiler’s murine encephalomyelitis virus-induced demyelinating disease. IV. Identification of an immunodominant T cell determinant on the N-terminal end of the VP2 capsid protein in susceptible SJL/J mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Class II-restricted T cell responses in Theiler’s murine encephalomyelitis virus-induced demyelinating disease. IV. Identification of an immunodominant T cell determinant on the N-terminal end of the VP2 capsid protein in susceptible SJL/J mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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