August 1, 1985The Journal of Immunology
Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in mice is influenced by the H-2D region: correlation with TEMV-specific delayed-type hypersensitivity.
Population
Crosses between SJL and several congenic H-2 recombinant mouse strains bearing different combinations of MHC…
Comparison
Intracranial inoculation of Theiler's murine… vs Comparison between different mouse…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Does not inform clinical practice; leaves open MHC-D region and DTH roles in human demyelinating disease.
Structured PICO
P
Population
Crosses between SJL and several congenic H-2 recombinant mouse strains bearing different combinations of MHC genes from the susceptible H-2s and resistant H-2b haplotypes on the C57BL/10 strain background
I
Intervention
Intracranial inoculation of Theiler's murine encephalomyelitis virus (TMEV)
C
Comparator
Comparison between different mouse strains/genotypes
O
Outcome
Development of demyelinating diseasesurrogate
TMEV-induced demyelinating disease in mice is likely immune-mediated, strongly correlating with the H-2D region genotype and TMEV-specific delayed-type hypersensitivity.
Cite This Study
Clatch et al. (1985) studied this question.