Population
Transgenic B10 (H-2) congenic mice expressing three independent contiguous coding regions of the Theiler's…
Comparison
Transgenic expression of TMEV viral capsid genes… vs Normally resistant B10 mice
Design
Preclinical
Authors
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Capsid expression may drive persistence and demyelination in this model; leaves open CD8+ T-cell roles in human CNS viral disease.
Transgenic expression of TMEV capsid genes inactivates virus-specific CD8+ T cells, leading to virus persistence and demyelination, highlighting the role of class I-restricted CD8+ T-cell responses in viral clearance and myelin protection.
Lin et al. (2002) studied this question.
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