September 1, 1993European Journal of Immunology
Class I‐deficient resistant mice intracerebrally inoculated with Theiler's virus show an increased T cell response to viral antigens and susceptibility to demyelination
Why the study?
Does the absence of functional class I/CD8+ cells increase susceptibility to TMEV-induced demyelination in mice?
Population
beta 2-microglobulin-deficient transgenic mice lacking class I expression and functional CD8+ T cells
Comparison
Intracerebral inoculation of Theiler's murine… vs TMEV-infected parental C57BL/6 mice
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Findings in CD8-deficient mice suggest protective rather than pathogenic role for CD8+ T cells; extends animal models but leaves open human translation.
Structured PICO
Does the absence of functional class I/CD8+ cells increase susceptibility to TMEV-induced demyelination in mice?
P
Population
beta 2-microglobulin (beta 2M)-deficient transgenic mice lacking class I expression and functional CD8+ T cells
I
Intervention
Intracerebral inoculation of Theiler's murine encephalomyelitis virus (TMEV)
C
Comparator
TMEV-infected parental C57BL/6 mice
O
Outcome
Disease susceptibility (virus-specific DTH, T cell proliferation, frequency of CNS demyelinating lesions, clinical signs of demyelination)surrogate
In a mouse model of TMEV-induced demyelination, CD8+ T cells appear to down-regulate potentially damaging CD4+ T cell responses rather than directly contributing to CNS demyelination.
Cite This Study
Pullen et al. (1993) studied this question.