Population
beta 2-microglobulin-deficient mice (beta 2m-/- mice) derived from a C57BL/6 x 129/Ola cross (H-2b haplotype)
Design
Preclinical
Authors
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May inform selective CD8+ modulation in viral CNS infection; leaves open translation to human demyelinating disease.
CD8+ T cells are required to clear Theiler's virus infection but are not major mediators of the resulting demyelinating disease.
Fiette et al. (1993) studied this question.
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