June 1, 1995The Journal of Experimental MedicineOpen Access

Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors.

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Population

Inbred 129Sv mice whose receptors for interferon alpha/beta or interferon gamma had been inactivated by…

Comparison

Infection with the Daniels strain of Theiler's… vs Control wild-type 129Sv mice

Design

Preclinical

Authors

LFLaurence FietteInstitut Pasteur CAC AubertDrexel University UMUlrike MüllerSanofi (France)

Discussion

Member takes

Implication

Distinct IFN roles in acute versus chronic viral encephalomyelitis in mice; leaves open translation to human CNS infections or demyelinating disease models.

Structured PICO

Population

Inbred 129Sv mice whose receptors for interferon alpha/beta or interferon gamma had been inactivated by homologous recombination, and control wild-type 129Sv mice.

Intervention

Infection with the Daniels strain of Theiler's virus

Comparator

Control wild-type 129Sv mice

Outcome

Disease outcome including encephalomyelitis severity, viral clearance, and demyelination

The interferon alpha/beta and interferon gamma systems play distinct, nonredundant roles in conferring resistance to Theiler's virus infection in mice.

Cite This Study

Fiette et al. (1995) studied this question.

synapsesocial.com/papers/6a899806f8670bac6e334cd9 https://doi.org/10.1084/jem.181.6.2069

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Implication

Distinct IFN roles in acute versus chronic viral encephalomyelitis in mice; leaves open translation to human CNS infections or demyelinating disease models.

Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider