Why the study?
Does the magnitude of the cytotoxic T-lymphocyte response determine viral persistence in mice infected with Theiler's virus?
Population
Genetically susceptible and resistant strains of mice infected with the DA strain of Theiler's virus
Comparison
Infection with the DA strain of Theiler's virus vs Comparison between resistant C57BL/6 mice and…
Design
Preclinical
Follow-up
1 to 2 weeks
Authors
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Higher CTL precursor frequency may limit Theiler's virus persistence in mice; leaves open translation to human picornaviral infections.
Does the magnitude of the cytotoxic T-lymphocyte response determine viral persistence in mice infected with Theiler's virus?
An efficient induction of virus-specific CTL precursors is critical for avoiding the establishment of a persistent picornaviral infection.
Dethlefs et al. (1997) studied this question.
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