Key result
MHC class II deficiency in mice prevented viral clearance and led to demyelination (47.8% at 45 days), whereas nonmutant mice cleared the virus and had no demyelination.
Why the study?
Does MHC class II deficiency affect virus clearance and demyelination in mice infected with Theiler's murine encephalomyelitis virus?
Does MHC class II deficiency affect virus clearance and demyelination in mice infected with Theiler's murine encephalomyelitis virus?
Absolute Event Rate: 47.8% vs 0%
MHC class II gene products are required for Theiler's virus clearance from the CNS but not for demyelination and neurologic disease.
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Caution against extrapolating to human CNS viral disease; leaves open MHC class II mechanisms in TMEV models for further preclinical study.
Njenga et al. (1996) studied Theiler's murine encephalomyelitis virus infection. MHC class II deficiency (Abo mutation) vs. Nonmutant H-2b mice was evaluated on Demyelination at 45 days. MHC class II deficiency in mice prevented viral clearance and led to demyelination (47.8% at 45 days), whereas nonmutant mice cleared the virus and had no demyelination.
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