November 1, 1990Journal of VirologyOpen Access

Major histocompatibility complex-conferred resistance to Theiler's virus-induced demyelinating disease is inherited as a dominant trait in B10 congenic mice

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Population

Congenic mice with different MHC haplotypes on identical B10 backgrounds and their F1 hybrid progeny

Design

Preclinical

Authors

APAmy K. PatickAmplyx Pharmaceuticals (United States)LPLarry R. PeaseMayo Clinic CDChella S. DavidUniversité de Tours

Discussion

Member takes

Implication

Supports dominant MHC resistance via antigen presentation in mice; leaves open translation to human demyelinating disease.

Structured PICO

Population

Congenic mice with different MHC haplotypes on identical B10 backgrounds (resistant B10, B10.D2, B10.K and susceptible B10.R111, B10.M, B10.BR) and their F1 hybrid progeny

Intervention

Intracerebral inoculation of Theiler's murine encephalomyelitis virus

Outcome

Demyelination, infectious virus, and local virus antigen productionsurrogate

MHC-conferred resistance to Theiler's virus-induced demyelinating disease is inherited as a dominant trait in B10 congenic mice, supporting the hypothesis that resistance is determined by efficient viral antigen presentation.

Cite This Study

Patick et al. (1990) studied this question.

synapsesocial.com/papers/6a895e3b1fb56efa37d447e1 https://doi.org/10.1128/jvi.64.11.5570-5576.1990

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Major histocompatibility complex-conferred resistance to Theiler's virus-induced demyelinating disease is inherited as a dominant trait in B10 congenic mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Major histocompatibility complex-conferred resistance to Theiler's virus-induced demyelinating disease is inherited as a dominant trait in B10 congenic mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider