Population
Susceptible H-2(q) FVB/N mice
Comparison
Transgenic expression of either the H-2D gene or… vs Transgenic expression of the H-2K(b) gene
Design
Preclinical
Authors
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H-2D(b) may enhance resistance via peptide presentation in this murine model; leaves open translation to human MHC class I and chronic viral disease.
The H-2D(b) gene confers resistance to persistent Theiler's murine encephalomyelitis virus infection due to the nature of the peptides presented by its class I molecules.
Azoulay-Cayla et al. (2001) studied this question.
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