Key result
Expression of the human HLA-B27 transgene in H-2s mice dramatically decreased the extent of demyelination and number of virus-Ag+ cells in the spinal cord compared with nontransgenic littermates.
Why the study?
Does expression of human HLA-B27 transgene alter susceptibility to Theiler's virus-induced demyelination in mice?
Population
Mice infected with Theiler's murine encephalomyelitis virus (strains H-2s, H-2f, H-2v, H-2b)
Comparison
Expression of human class I MHC gene transgene vs Nontransgenic littermate mice
Design
Preclinical
Follow-up
45 days
Authors
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HLA-B27 modulates viral demyelination in mice; leaves open its relevance to human CNS autoimmunity.
Does expression of human HLA-B27 transgene alter susceptibility to Theiler's virus-induced demyelination in mice?
Expression of a human class I MHC gene (HLA-B27) can modulate a virus-induced demyelinating disease process in the mouse.
Rodriguez et al. (1991) studied Theiler's murine encephalomyelitis virus-induced demyelination. Expression of human HLA-B27 transgene vs. Nontransgenic littermate mice was evaluated on Extent of demyelination and number of virus-Ag+ cells in the spinal cord. Expression of the human HLA-B27 transgene in H-2s mice dramatically decreased the extent of demyelination and number of virus-Ag+ cells in the spinal cord compared with nontransgenic littermates.
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