Key result
In genetically susceptible mice infected with TMEV, a significantly greater increase in D expression relative to K expression was seen in the CNS compared to resistant mice.
Differences in the regulation of H-2K and H-2D gene expression in the CNS may account for the different roles these loci play in determining resistance and susceptibility to TMEV-induced demyelinating disease.
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May guide genetic studies of CNS viral susceptibility; leaves open translation to human demyelinating disease.
Altıntaş et al. (1993) studied Theiler's murine encephalomyelitis virus (TMEV) induced demyelination. Theiler's murine encephalomyelitis virus (TMEV) infection vs. Resistant vs susceptible mice was evaluated on Expression of K and D Ag in the central nervous system. In genetically susceptible mice infected with TMEV, a significantly greater increase in D expression relative to K expression was seen in the CNS compared to resistant mice.
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