Key result
In TMEV-infected SJL/J mice, 13.5% to 25% of CNS CD4+ T cells expressed high affinity IL-2R compared to 2% to 8.5% in the spleen, suggesting a CD4+ Th1 cell-mediated demyelinating process.
Population
SJL/J mice infected with Theiler's murine encephalomyelitis viruses and experimental autoimmune…
Design
Preclinical
Follow-up
up to 119 days postinfection
Authors
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CNS enrichment of activated CD4+ T cells supports Th1-driven demyelination in TMEV models; leaves open therapeutic targeting in human disease.
The findings suggest that a polyclonal population of TMEV-specific, CD4+ Th1 cells plays a major effector role in the demyelinating process in this murine model.
Pope et al. (1996) studied Theiler's virus-induced demyelinating disease. Theiler's murine encephalomyelitis virus (TMEV) infection was evaluated on Proportion of CD4+ T cells expressing high affinity IL-2R in the CNS versus spleen. In TMEV-infected SJL/J mice, 13.5% to 25% of CNS CD4+ T cells expressed high affinity IL-2R compared to 2% to 8.5% in the spleen, suggesting a CD4+ Th1 cell-mediated demyelinating process.
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