Key result
Depletion of complement components with cobra venom factor significantly increased demyelinating lesions in TMEV-infected mice, not supporting a humoral autoimmune basis for CNS demyelination.
Population
Susceptible SJL mice with intracerebral inoculation of Theiler's murine encephalomyelitis virus (TMEV)
Comparison
Depletion of complement components with cobra… vs Infected mice without complement depletion
Design
Preclinical
Authors
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Animal data caution against complement inhibition in viral CNS demyelination; leaves open complement's role in MS pathogenesis.
The data suggest that CNS demyelination in persistent TMEV infection is not driven by a humoral autoimmune response against myelin, and complement depletion actually increases demyelinating lesions.
Rodriguez et al. (1988) studied Demyelination induced by Theiler's murine encephalomyelitis virus (TMEV). Depletion of complement components with cobra venom factor vs. No depletion was evaluated on Demyelinating lesions. Depletion of complement components with cobra venom factor significantly increased demyelinating lesions in TMEV-infected mice, not supporting a humoral autoimmune basis for CNS demyelination.
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