April 1, 2002Annals of the New York Academy of Sciences
Theiler's Virus‐Mediated Autoimmunity
Key result
This review discusses the initiation of a virally induced CD4+ T cell-mediated autoimmune response, epitope spreading, and antigen presentation in Theiler's murine encephalomyelitis virus infection.
Population
SJL/J mouse model of Theiler's murine encephalomyelitis virus infection
Design
Review
Authors
Discussion
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Member takes
Implication
May inform virus-triggered CNS autoimmunity models; leaves open human disease translation.
Structured PICO
P
Population
SJL/J mouse model of Theiler's murine encephalomyelitis virus (TMEV) infection (preclinical model for multiple sclerosis)
E
Exposure
Theiler's murine encephalomyelitis virus (TMEV) infection
O
Outcome
Mechanisms of virally induced CD4+ T cell-mediated autoimmune response, epitope spreading, and chronic myelin damage
This review summarizes the mechanisms by which TMEV infection in mice induces a chronic, CD4+ T cell-mediated demyelinating disease via epitope spreading, serving as a model for multiple sclerosis.
Cite This Study
Tompkins et al. (2002) conducted a review in Theiler's murine encephalomyelitis virus (TMEV) infection / multiple sclerosis model. Theiler's murine encephalomyelitis virus (TMEV) infection was evaluated. This review discusses the initiation of a virally induced CD4+ T cell-mediated autoimmune response, epitope spreading, and antigen presentation in Theiler's murine encephalomyelitis virus infection.