Population
Female SJL/J mice
Comparison
Theiler's murine encephalomyelitis virus… vs Mock infection, vaccinia virus infection, or…
Design
Preclinical
Follow-up
3 weeks post-infection; 6 or 10 days post-adoptive transfer
Authors
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Findings remain preclinical; leaves open whether Fas-FasL CD8+ autoreactivity drives human CNS autoimmunity.
TMEV infection can induce autoreactive CD8+ cytotoxic T cells that mediate central nervous system pathology, providing a potential mechanism for virus-induced autoimmunity.
Tsunoda et al. (2002) studied this question.
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