Key result
Theiler's murine encephalomyelitis virus induces an inflammatory demyelinating disease in mice resembling multiple sclerosis, driven by viral persistence and the immune system.
Population
Mice infected with Theiler's murine encephalomyelitis virus (TMEV)
Design
Review
Authors
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Supports TMEV as MS model; leaves open human translation pending clinical validation.
This review summarizes the pathogenesis of TMEV-induced demyelinating disease, a viral model for multiple sclerosis.
Raymond P. Roos (2010) conducted a review in Theiler's murine encephalomyelitis virus-induced demyelinating disease. Theiler's murine encephalomyelitis virus (TMEV) was evaluated. Theiler's murine encephalomyelitis virus induces an inflammatory demyelinating disease in mice resembling multiple sclerosis, driven by viral persistence and the immune system.
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